serotyping, antibiotic susceptibility and related risk factors aspects of nasopharyngeal carriage of streptococcus pneumoniae in healthy school students.
نویسندگان
چکیده
streptococcus pneumoniae is an important problem worldwide and nasopharyngeal colonization plays significant role in pneumococcal infections. the aims of this study were to determine the nasopharyngeal colonization rate, serotyping, antibiotics susceptibility and study the risk factors for nasopharyngeal colonization with s. pneumoniae in students in kashan, iran.a cross-sectional study was conducted on children aged 7 to 19 years from december 2011 to november 2012. nasopharyngeal swabs were plated onto brain heart infusion agar plates with 5% sheep blood and 4µg/ml of gentamycin. antimicrobial susceptibility profiles were determined on mueller-hinton agar in accordance with clsi. s. pneumoniae strains were investigated for the presence of the most common pneumococcal serotypes using a multiplex polymerase chain reaction.13.9% were found to be carriers. the most prevalent serogroups were 19f (30%), 6a/b (18.9%), 15a (16.5%), 11 (11.3%), 23f (8.2%), 1 (6.2%), 19a (3.4%), and 35b (2.4%). nine strains (3.1%) were non-typeable. the carrier rate was significantly higher in 12 to15 year old age group. upper respiratory tract infections within the last month (or=1.5, p<0.011), previous hospitalization (or=1.6, p<0.001), previous antibiotic usage last two weeks (or=1.89, p<0.001), rhinorea (or=1.9 p<0.001), male sex (or=3.5 p< 0.001) and passive smoking (or=1.56, p< 0.001) have been determined to be risk factors for s. pneumoniae carriage. the highest pneumococcal resistance was to tetracycline (25.4%). all strains were susceptible to linezolid and levofloxacin.our information leads to an important source to screen the future impact of pneumococcal vaccination on bacterial colonization.
منابع مشابه
Serotyping, Antibiotic Susceptibility and Related Risk Factors Aspects of Nasopharyngeal Carriage of Streptococcus pneumoniae in Healthy School Students
BACKGROUND Streptococcus pneumoniae is an important problem worldwide and nasopharyngeal colonization plays significant role in pneumococcal infections. The aims of this study were to determine the nasopharyngeal colonization rate, serotyping, antibiotics susceptibility and study the risk factors for nasopharyngeal colonization with S. pneumoniae in students in Kashan, Iran. METHODS A cross-s...
متن کاملnasopharyngeal carriage, antibiotic resistance and serotype distribution of streptococcus pneumoniae among healthy adolescents in zahedan
متن کامل
Nasopharyngeal carriage, antibiotic resistance and serotype distribution of Streptococcus
Abstract Background and objectives: Colonization of nasopharynx by Streptococcus Pneumoniae can lead to pneumococcal disease. This study was performed to determine the carriage rate of nasopharyngeal S.pneumoniae in adolescents and their antibiotic susceptibility and serotype prevalence in Zahedan, Iran Material and Methods: Nasopharyngeal specimens were obtained from 865 adolescents aged 10-19...
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Streptococcus pneumoniae carriage is a risk factor for the development of respiratory system infections and the spread of penicillin-resistant strains. The aim of this study was to investigate nasopharyngeal carriage of S. pneumoniae in healthy children and resistance to penicillin and other antimicrobials and to assess related risk factors. Nasopharyngeal specimens collected from healthy child...
متن کاملNasopharyngeal Carriage, Antibiotic Resistance and Serotype Distribution of Streptococcus Pneumoniae among Healthy Adolescents in Zahedan
BACKGROUND Colonization of nasopharynx by Streptococcus pneumoniae can lead to pneumococcal diseases. This study was performed to determine the carriage rate of nasopharyngeal S. pneumoniae in adolescents, antibiotic susceptibility and serotype prevalence in Zahedan, Iran. METHODS Nasopharyngeal specimens from 865 adolescents (age range: 10-19 years old) attending eight schools in Zahedan, Ir...
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عنوان ژورنال:
iranian journal of public healthجلد ۴۳، شماره ۹، صفحات ۱۲۸۴-۹۰
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